20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0687 | Simvastatin | MK-0733,MK 733 | Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy |
Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovasc... | |||
T4970 | LANOSTEROL | 3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol | Endogenous Metabolite |
Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived. | |||
T15720 | Lathosterol | Endogenous Metabolite | |
Lathosterol, a molecule akin to cholesterol, serves as a biomarker for the body's total cholesterol synthesis, as indicated by its serum concentration. | |||
T0760 | Cholesterol | Cholesterin,Cholesteryl alcohol | Estrogen Receptor/ERR , MRP , Endogenous Metabolite , ROR |
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also us... | |||
TMA2440 | Uridine 5'-monophosphate disodium salt | Disodium UMP,Disodium uridine-5'-monophosphate,5'-UMP disodium salt,Disodium 5'-Uridylate | Others |
Uridine 5'-monophosphate disodium salt (Disodium UMP) has been used to study the effect of pyrimidine synthesis inhibitor, 5-azacytidine, on cholesterol and lipid metabolism. It has been used to study the effect of nucle... | |||
T17190 | U18666A | Others , HCV Protease | |
U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus. | |||
T35371 | Colesevelam Hydrochloride | Others | |
Colesevelam Hydrochloride is a bile acid sequestrant with a higher affinity for glycocholic acid in vitro. Colesevelam Hydrochloride inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduces c... | |||
T4317 | PF 429242 | NPC1L1 , Lipid | |
PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rat... | |||
T76739 | Bococizumab | RN316,PF-04950615 | Others |
Bococizumab(PF-04950615) is a humanized mAb against PCSK9 and an inhibitor of the synthesis of PCSK9 in the liver that reduces the amount of low-density lipoprotein cholesterol (LDL-C) in the blood.Bococizumab is used to... | |||
T1415 | Gemfibrozil | CI-719,Jezil,Decrelip,Lopid | P450 , Adrenergic Receptor , PPAR |
Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfi... | |||
T4749 | Squalene | Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene | Reactive Oxygen Species , Endogenous Metabolite , Antifungal |
Squalene (AddaVax) is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. All hi... | |||
T5S0053 | Coptisine | Coptisin | Indoleamine 2,3-Dioxygenase (IDO) |
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ... | |||
TCS2070 | Homogentisic acid | 2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid | Antioxidant , Endogenous Metabolite |
1. Homogentisic acid (2,5-dihydroxyphenylacetic acid) shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation, comparable to those of well known antioxidant... | |||
T6480 | D-Pantothenic acid | vitamin B5,pantothenate | Others |
D-Pantothenic acid (vitamin B5) is a water-soluble vitamin ubiquitously found in plants and animal tissues with an antioxidant property. D-Pantothenic acid is a component of coenzyme A (CoA) and a part of the vitamin B2 ... | |||
T4947 | 3-Hydroxybutyric acid | Butanoic acid | Endogenous Metabolite |
3-Hydroxybutyric acid (Butanoic acid) (or beta-hydroxybutyrate) is a ketone body. Like the other ketone bodies (acetoacetate and acetone), levels of 3-hydroxybutyrate in blood and urine are raised in ketosis. In humans, ... | |||
T40898 | DMHCA | ||
DMHCA, a potent, selective LXR agonist, specifically activates the LXR pathway's cholesterol efflux arm, avoiding triglyceride synthesis stimulation. This compound exhibits anti-inflammatory properties and is utilized in... | |||
T26548 | Acaterin | ||
Acaterin, an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), inhibits synthesis of cholesteryl ester in macrophage J774. | |||
T83159 | Agistatin B | ||
Agistatin B, a mycotoxin isolated from fungus, inhibits cholesterol synthesis [1]. | |||
T38088 | 28-Deoxybetulin methyleneamine | ||
28-Deoxybetulin methyleneamine is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It has been used in the synthesis of triterpene derivatives with antiviral activity. 1.Nitz,... | |||
T41015 | Larsucosterol | DUR-928 | |
Larsucosterol is a cholesterol metabolite from the nuclei of normal human liver tissues, epigenetically regulates the transcription of proteins and enzymes involved in lipid synthesis, inflammation, and apoptosis. |